To assess the benefits and harms of SUP compared to placebo in adult critically ill patients in the ICU.
The level of evidence for the use of SUP in the ICU is low/very low.
A systematic review and meta-analysis.
Adult critically ill patients in the ICU.
The following databases will be systematically searched for literature: MEDLINE including MeSH (from January 1966), EMBASE (from January 1980), and the Cochrane Library (latest issue). Search terms: 1) stress AND ulcer AND prophylaxis, 2) stress AND ulcer AND prevention, and 3) stress AND ulcer AND control. In addition, references of relevant studies will be hand-searched. Only RCTs will be included in the review.
Individual and pooled RRs with 95% CIs, assessment of risk of bias, and Trial Sequence Analysis (TSA).
Registration and approval
The manuscript will be prepared according to the Cochrane Handbook methodology, and registered in the International Prospective Register of Systematic Reviews (PROSPERO).