To highlight unanswered clinical research questions on SUP in adult ICU patients.
The rationale of SUP in the ICU is widely unresolved, and the level of evidence is low.
A topical systematic review.
Adult critically ill patients in the ICU receiving SUP.
The following databases will be systematically searched for literature: MEDLINE including MeSH (from January 1966), EMBASE (from January 1980), and the Cochrane Library (latest issue). Search terms: 1) stress AND ulcer AND prophylaxis, 2) stress AND ulcer AND prevention, and 3) stress AND ulcer AND control. In addition, references of relevant studies will be hand-searched. No study-designs will per-se be excluded of the review.
The level of evidence will be assessed according to GRADE.
Registration and approval
The manuscript will be prepared according to the PRISMA Statement, and registered in the International Prospective Register of Systematic Reviews (PROSPERO).